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KMID : 1007020030010010001
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Korean Soceity of Osteroporosis
2003 Volume.1 No. 1 p.1 ~ p.11
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The Regulation Mechanims of Runx2 by FGF/FGFR Signaling During Osteoblast Differentiation
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Kim Hyun-Jung
Ryoo Hyun-Mo
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Abstract
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Fibroblast growth factors (FGFs) and their receptors (FGFRs) play crucial roles for bone formation during embryonic development. Mutations in three FGFRs(FGFR1-3) underlie several autosomal dominant skeletal syndromes such as dwarfism and various craniosynostosis syndromes(CS). The constitutive activation of these receptors by the point mutations of FGFR1-3 causes CS resulting from the acceleration of osteoblast differentiation, which subsequently results in premature closure of epiphysis of long bones or sutures of flat bones. On the contrary, cleidocranial dysplasia(CCD) characterized by delayed ossification is caused by haploinsufficiency of Runx2 gene. Recent reports showed that the activation of FGF/FGFR signaling stimulates Runx2 expression and activity, suggesting that Runx2 is a major target gene of FGF/FGFR signaling during osteoblast differentiation. Therefore, in this present paper, we summarized the regulation mechanism of Runx2 by FGF/FGFR signaling in osteoblast differentiation.
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KEYWORD
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Fibroblast growth factors, fibroblast growth factor receptors (FGF/FGFR), Craniosynostosis, Osteoblast, Runx2
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